鄧恒為

博士，副教授、博士生導師

個人簡介：

中山大學理學博士、博士後，海南自貿港D類人才，中國-東盟海水養殖技術“一帶一路”聯合實驗室國際合作科技特派員。主要從事海洋動物分子免疫學及海洋生物病原分子生物學的研究。主持國家自然科學基金2項、廣東省自然科學基金1項、365英国上市官网在线啟動基金1項及福建省重點實驗室開發課題1項，參與多項國家自然科學基金項目。發表論文25篇，其中SCI論文20篇，申請專利2項。

研究方向：

1. 甲殼動物抗病毒免疫分子機制

2. 水生動物先天性免疫調控機制

3. 病毒功能基因、緻病機理及其與宿主的相互作用

研究項目：

1. 國自然地區科學基金，32260924，拟穴青蟹SOCS2介導的JAK/STAT通路負反饋環路及其對機體免疫穩态調控的分子機制，2023/01-2026/12，主持

2. 國自然青年科學基金，32002440，拟穴青蟹幹擾素調節因子調控幹擾素誘導基因ISG12抗病毒的分子機制，2021/01-2023/12，主持

3. 廣東省自然科學基金面上項目，2022A1515010958，拟穴青蟹SOCS2負反饋調控JAK/STAT通路參與抗病毒免疫反應，2022/01-2024/12，主持

4. 365英国上市官网在线科研啟動項目，拟穴青蟹幹擾素誘導基因IFI27L2抗病毒的分子機制，2022/02-2027/02，主持

5. 福建省海洋漁業資源與生态環境重點實驗室課題，JAK-STAT通路調控拟穴青蟹免疫穩态的分子機制及抗病毒效應，2023/10-2025/10，主持

6. 國家自然科學基金面上項目，32073004，p38 MAPK信号通路調控凡納濱對蝦血淋巴透明細胞吞噬功能活化的分子機制，2021/01-2024/12，參與

7. 國家自然科學基金面上項目，31672677，青蟹呼腸孤病毒（MCRV）與青蟹雙順反子病毒（MCDV）共感染及相互影響機制，2017/01-2020/12，參與

代表論文：

1. Hengwei Deng, Danrong Xian, Taixin Lian, Mingyu He, Jingjing Li, Xiaopeng Xu, Zhixun Guo, Jianguo He*, Shaoping Weng*, A Dicer2 from Scylla paramamosain activates JAK/STAT signaling pathway to restrain mud crab reovirus, Developmental and Comparative Immunology, 127(2022)104267.

2. Hengwei Deng, Yeyu Li, Jinling Li, Wenjie Shen, Qiankang Chen, Shaoping Weng, Jianguo He, Xiaopeng Xu*, Neomycin inhibits Megalocytivirus infection in fish by antagonizing the increase of intracellular reduced glutathione, Fish & Shellfish Immunology, 127(2022), 148-154.

3. Hengwei Deng, Lei Hu, Jingjing Li, Wenyan Yan, Enhui Song, Mingqing Kuang, Shanshan Liu, Jianguo He*, Shaoping Weng*, The NF-κB family member dorsal plays a role in immune response against Gram-positive bacterial infection in mud crab (Scylla paramamosain), Developmental and Comparative Immunology,106 (2020) 103581.

4. Hengwei Deng, Wenfeng Zhang, Jingjing Li, Jinling Li, Lei Hu, Wenyan Yan, Shanshan Liu, Jianguo He*, Shaoping Weng*, A signal transducers and activators of transcription (STAT) gene from Scylla paramamosain is involved in resistance against mud crab reovirus, Fish and Shellfish Immunology,94 (2019) 580-591.

5. Hengwei Deng, Xiaopeng Xu, Lei Hu, Jingjing Li, Dandan Zhou, Shanshan Liu, Panpan Luo, Jianguo He*, Shaoping Weng*, A janus kinase from Scylla paramamosain activates JAK/STAT signaling pathway to restrain mud crab reovirus, Fish and Shellfish Immunology,90 (2019) 275-287.

6. Deng Hengwei, Li Zhongbao*, Dai Gang, Yuan Yi, Ning Yefeng, Shangguan Jingbo, Huang Yesheng. Isolation of new polymorphic microsatellite markers from the marbled rockfish Sebastiscus marmoratus. Genetics and molecular research, 14(2015): 758-762.

7. Wei-Liang Guo, Heng-Wei Deng, Fei Wang, Shi-Feng Wang, Zhi-Hong Zhong, Yun Sun, Xue-Fen Chen, Jin-Hua Wang, Yong-Can Zhou*. In vitro and in vivo screening of herbal extracts against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture 503 (2019) 412-421.

8. Jiefeng Gao^#, Ran Geng^#, Hengwei Deng, Hongliang Zuo, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A novel Forkhead box protein P (FoxP) from Litopenaeus vannamei plays a positive role in immune response. Frontiers in Immunology, 11(2020):593987.

9. Wenfeng Zhang, Hengwei Deng, Yuting Fu, Weixuan Fu, Shaoping Weng, Jianguo He, Chuanfu Dong*. Production and characterization of monoclonal antibodies against mandarinfish ranavirus and first identification of pyloric caecum as the major target tissue. Journal of Fish Diseases, 0(2022), 1–11.

10. Shoujia Jiang^#, Lijun Fu^#, Zijian Gao, Hengwei Deng, Yong Zhang, Xinxin You, Qiong Shi, Danqi Lu*. Multi-Omics Study on the Molecular Mechanisms of Tetraodon Nigroviridis Resistance to Exogenous Vibrio Parahaemolyticus Infection. Frontiers in Marine Science. 9(2022):914028.

11. Linwei Yang, Ziang Wang, Ran Geng, Hengwei Deng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu. White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki to Promote Its Infection in Penaeus vannamei. Microbiol Spectr. 11(2023):0236322.

12. Jian-Hui He, Wenjie Shen, Deyu Han, Muting Yan, Mengting Luo, Hengwei Deng, Shaoping Weng, Jianguo He, Xiaopeng Xu. Molecular mechanism of the interaction between Megalocytivirus-induced virus-mock basement membrane (VMBM) and lymphatic endothelial cells. J Virol. 97(2023):0048023.

13. 鄧恒為,郭偉良,孫曉飛,等.響應面法優化丹參中抗無乳鍊球菌活性成分的提取工藝[J].漁業科學進展, 2014,35(4):132-140.

14. 鄧恒為,周永燦,郭偉良,等.抗哈氏弧菌中草藥篩選及其活性成份提取工藝的優化[J].水産科學, 2013, 32 (5):249-255.

15. 胡蕾,鄧恒為,李晶晶,劉姗姗,何建國,李海雲,翁少萍.拟穴青蟹Cactus基因的cDNA克隆、序列及生物學功能[J].水産學報,2020,44(01):21-32.

聯系方式

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