曹貞潔

博士、副教授、博士生導師

個人簡介

365英国上市官网在线水生生物學博士，博士後。365英国上市官网在线D類高層次引進人才，入選海南省自由貿易港D類高層次人才計劃。主持國家自然科學基金青年基金1項，海南省重點研發項目1項，海南省自然科學基金1項，365英国上市官网在线科研啟動基金項目1項，海南省博士後面上項目1項。參與國家重點研發計劃、國家自然科學基金、海南省重大科技專項、海南省重點研發等課題多項。出版專著1部，發表高水平學術論文20餘篇（第一或通訊作者發表SCI論文14篇），授權國際發明專利1項，國内發明專利2項。

學術成果

長期開展卵形鲳鲹、駝背鲈等海水魚類免疫相關分子及其作用機制等研究，為魚類健康養殖提供新的策略。目前研究方向主要集中在以下三方面：

1. 熱帶魚類的免疫應答機制及病害防控

2. 熱帶魚類免疫增強劑的研發與應用

3. 熱帶魚類重要病原的快速檢測技術研發

研究項目

1. 國家自然科學基金青年基金，卵形鲳鲹Bcl-2/Bok介導的線粒體凋亡途徑參與機體免疫應答的作用和機制研究，2024.01-2026.12，主持，在研；

2. 海南省重點研發計劃項目，基于多重可視化LAMP的石斑魚類重要病原多目标檢測技術研發與初步應用，2022.03.16-2024.03.16，主持，在研；

3. 海南省自然科學基金青年基金項目，卵形鲳鲹NK-lysin的抗菌機制及其介導的先天免疫應答研究，2020.12.26-2023.12.25，主持，結題；

4. 海南省博士後基金面上資助，駝背鲈MHC基因多态性分析及其與魚體抗病力相關性研究，2017.11-2019.07，主持，結題；

5. 365英国上市官网在线高層次人才科研啟動項目，熱帶海水魚類的主要免疫相關基因及其抗病機制研究，2019.12-2024.12, 100萬元，主持，在研

代表性成果

1. Zhenjie Cao#1, Xin Yang#1, Tao Li#1, Zhiru Liu, Pengfei Li, Yongcan Zhou, Yun Sun*. Molecular characterization and expression analysis of B-cell lymphoma-2 in Trachinotus ovatus (TroBcl-2) and its role in apoptotic process. Frontiers in Immunology, 2023, 14: 1129800.

2. Yun Sun#1, Zhenjie Cao#1, Panpan Zhang, Caoying Wei, Jianlong Li, Ying Wu*, Yongcan Zhou*. IFN regulatory factor 3 of golden pompano and its NLS domain are involved in antibacterial innate immunity and regulate the expression of type I interferon (IFNa3). Frontiers in immunology, 2023, 14: 1128196.

3. Yang Lei#1, Zhenjie Cao#1, Yongwei Hou, Xiangyu Du, Han Zhang, Hehe Du, Yongcan Zhou*, Yun Sun*. Molecular characterization and functional analysis of tartrate-resistant acid phosphatase (ACP5) gene in red drum (Sciaenops ocellatus). Fish & Shellfish Immunology, 2023, 132, 108495.

4. Han Zhang, Haoran Yang, Pengsuo Li, Na Zhao, Xiaojuan Chen, Yongcan Zhou, Zhenjie Cao*, Yun Sun*. Selection of the appropriate reference genes by quantitative real-time PCR in leopard coral groupers (Plectropomus leopardus). Journal of Oceanology and Limnology, 2023, 41(3), 1084-1099.

5. Hehe Du#1, Zhenjie Cao#1, Zhiru Liu, Guotao Wang, Ying Wu, Xiangyu Du, Caoying Wei, Yun Sun*, Yongcan Zhou*. Cromileptes altivelis microRNA transcriptome analysis upon nervous necrosis virus (NNV) infection and the effect of cal-miR-155 on cells apoptosis and virus replication. Viruses, 2022, 14, 2184.

6. Han Zhang#1, Zhenjie Cao#1, Qianying Diao, Yongcan Zhou, Jingqun Ao, Chunsheng Liu*, Yun Sun*. Antimicrobial activity and mechanisms of a derived antimicrobial peptide TroNKL-27 from golden pompano (Trachinotus ovatus) NK-lysin. Fish & Shellfish Immunology, 2022. 126, 357-369.

7. Han Zhang, Haoran Yang, Pengsuo Li, Na Zhao, Xiaojuan Chen, Yongcan Zhou, Cao, Zhenjie Cao*, Yun Sun*. Selection of the appropriate reference genes by quantitative real-time PCR in leopard coral groupers (Plectropomus leopardus). Journal of Oceanology and Limnology, 2022, https://doi.org/ 10.1007/s00343-022-2027-z.

8. Xiaojuan Chen#1, Zhenjie Cao#1, Zhengshi Zhang, Ying Wu, HeHe Du, Yun Sun*, Yongcan Zhou*. B lymphocyte stimulating factor of Trachinotus ovatus (TroBLyS) promotes antibacterial immune defense. Aquaculture, 2021, 536:736437.

9. Yixuan Liu#1, Caoying Wei#1, Zhiru Liu, Zhenjie Cao*, Yun Sun*, Yongcan Zhou, Shifeng Wang, Weiliang Guo. Establishment of a new fish cell line from the brain of humpback grouper (Cromileptes altivelis) and its application in toxicology and bacterial susceptibility. Fish Physiology and Biochemistry, 2021. 47(5), 1645-1658.

10. Lu Wang#1, Zhenjie Cao#1, Yixuan Liu, Yajing Xiang, Yun Sun*, Yongcan Zhou*, Shifeng Wang, Weiliang Guo. Establishment and characterization of a new cell line from the muscle of humpback grouper (Cromileptes altivelis). Fish Physiology and Biochemistry, 2020, 46, 1897-1907.

11. Xiaojuan Chen#, Yun Sun#, Panpan Zhang, Jianlong Li, Haiping Li, Caoying Wei, Zhenjie Cao*, Yongcan Zhou*. Screening of stable internal reference genes by quantitative real-time PCR in humpback grouper (Cromileptes altivelis). Journal of Oceanology and Limnology, 2020, 1-15.

12. Yun Sun, Yajing Xiang, Mingwang He, Xiang Zhang, Shifeng Wang, Weiliang Guo, Chunsheng Liu, Zhenjie Cao*, Yongcan Zhou*. Evaluation of Lactococcus lactis HNL12 combined with Schizochytrium limacinum algal meal in diets for humpback grouper (Cromileptes altivelis). Fish & Shellfish Immunology, 2019. 94: 880-888.

13. Zhenjie Cao, Xiaocen Liu, Yajing Xiang, Lu Wang, Yun Sun, Yongcan Zhou. Genetic polymorphism of MHC class IIα alleles and its association with resistance/susceptibility to viral nervous necrosis virus (VNNV) in golden pompano (Trachinotus ovatus). Aquaculture, 2019, 501:144-152.

14. Zhenjie Cao, Lu Wang, Yajing Xiang, Xiaocen Liu, Zhigang Tu, Yun Sun, Yongcan Zhou. MHC class IIα polymorphism and its association with resistance susceptibility to Vibrio harveyi in golden pompano (Trachinotus ovatus). Fish & Shellfish Immunology, 2018, 80:302-310.

15. Zhenjie Cao, Mingwang He, Xiaojuan Chen, Shifeng Wang, Yan Cai, Zhenyu Xie, Yun Sun, Yongcan Zhou. Identification, polymorphism and expression of MHC class Iα in golden pompano, Trachinotus ovatus. Fish & Shellfish Immunology, 2017, 67: 55-65.

16. 孫雲，何明旺，張盼盼，李海平，曹貞潔*，周永燦*. 美洲鳗鲡緻病性鮑曼不動杆菌的分離、鑒定及緻病性分析. 水産學報, 2020, 44(9): 1561−1571.

招生專業

水産學術碩士、漁業發展專業碩士，歡迎同學們積極聯系報考。

聯系方式

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